A DNA hypermethylation profile reveals new potential biomarkers for prostate cancer diagnosis and prognosis

Ashour, Nadia; Angulo Cuesta, Javier; Andrés, Guillermo; Alelú, Raúl; González-Corpas, Ana; Toledo, María V.; Rodríguez-Barbero, José M.; López, José Ignacio; Sánchez-Chapado, Manuel; Ropero, Santiago

doi:10.1002/pros.22833

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A DNA hypermethylation profile reveals new potential biomarkers for prostate cancer diagnosis and prognosis

Ashour, Nadia; Angulo Cuesta, Javier; Andrés, Guillermo; Alelú, Raúl; González-Corpas, Ana; Toledo, María V.; Rodríguez-Barbero, José M.; López, José Ignacio; Sánchez-Chapado, Manuel; Ropero, Santiago

Use este identificador para citar o enlazar este ítem: http://hdl.handle.net/11268/4230

Fecha: 2014

Materia UNESCO: Cáncer

Tipo: article

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Resumen:

DNA hypermethylation has emerged as a novel molecular biomarker for the evaluation of prostate cancer diagnosis and prognosis. Defining the specific gene hypermethylation profile for prostate cancer could involve groups of genes that specifically discriminate patients with indolent and aggressive tumors. Genome-wide methylation analysis was performed on 83 tumor and 10 normal prostate samples using the GoldenGate Methylation Cancer Panel I (Illumina, Inc.). All clinical stages of disease were considered.

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