Mostrar el registro sencillo del ítem
dc.contributor.author | Garatachea, Nuria | |
dc.contributor.author | Marín, Pedro J. | |
dc.contributor.author | Santos-Lozano, Alejandro | |
dc.contributor.author | Sanchís-Gomar, Fabián | |
dc.contributor.author | Emanuele, Enzo | |
dc.contributor.author | Lucía Mulas, Alejandro | |
dc.date.accessioned | 2015-06-23T07:57:37Z | |
dc.date.available | 2015-06-23T07:57:37Z | |
dc.date.issued | 2015 | |
dc.identifier.citation | Garatachea, N., Marín, P. J., Santos-Lozano, A., Sanchís-Gomar, F., Emanuele, E., & Lucía, A. (2015). The ApoE Gene Is Related with Exceptional Longevity: A Systematic Review and Meta-Analysis. Rejuvenation research, 18(1), 3-13. | spa |
dc.identifier.issn | 15491684 | |
dc.identifier.issn | 15578577 | |
dc.identifier.uri | http://hdl.handle.net/11268/4026 | |
dc.description.abstract | The objective of this meta-analysis was to determine the association of the apolipoprotein E (ApoE) gene with exceptional longevity (EL) (i.e., reaching 100+ years) by identifying possible unequal distribution of alleles/genotypes in the common variants ε2, ε3, and ε4 among centenarians and younger population. The association of ApoE with EL was analyzed in a total of 2776 centenarians (cases) and 11,941 younger controls (from 13 case-control studies) using the chi-squared test with the Yates correction. We conducted combined and separate analyses for all ethnic groups studied in the literature (Caucasian and Asian). The present meta-analysis confirms that, besides its previously documented influence on Alzheimer's and cardiovascular disease risk, the ApoE gene is associated with the likelihood of reaching EL. | spa |
dc.description.sponsorship | Proyecto PI12/00914 (Fondo de Investigaciones Sanitarias) | spa |
dc.language.iso | eng | spa |
dc.title | The ApoE gene is related with exceptional longevity: a systematic review and meta-analysis | spa |
dc.type | article | spa |
dc.description.impact | 3.664 JCR (2015) Q2, 10/49 Geriatrics & gerontology | spa |
dc.identifier.doi | 10.1089/rej.2014.1605 | |
dc.rights.accessRights | closedAccess | spa |
dc.subject.uem | Envejecimiento | spa |
dc.subject.uem | Genética | spa |
dc.subject.unesco | Ciencia | spa |
dc.subject.unesco | Envejecimiento | spa |
dc.subject.unesco | Genética humana | spa |
dc.description.filiation | UEM | spa |
dc.peerreviewed | Si | spa |
Ficheros | Tamaño | Formato | Ver |
---|---|---|---|
No hay ficheros asociados a este ítem. |