Resumen:
This study assesses the incidence of hepatocellular
carcinoma (HCC) in a prospective cohort of HIV-infected patients,
the majority receiving antiretroviral therapy, with liver cirrhosis from
different etiologies, enrolled between 2004 and 2005 with median
follow-up of 5 years. We followed 371 patients, 25.6% with
decompensated cirrhosis at baseline. The incidence rate of HCC
was 6.72 per 1000 person-years [95% confidence interval (CI): 2.6 to
10.9]. There was a trend toward a higher cumulative probability of
developing HCC at 6 years of follow-up (considering death and liver
transplant as competing risks) in patients with decompensated versus
compensated cirrhosis at baseline (6% vs. 2%, P , 0.06).
Key Words: HIV, viral hepatitis, liver cirrhosis, hepatocellular
carcinoma, incidence