Resumen:
The metabolic syndrome (MS) has been related to the development of renal disease in different populations. Our aim was to study the association of MS with chronic renal disease a hypertensive population. We did the study between a population of 1231 patients attended in our Hypertension Unit with a previous diagnosis of essential hypertension we selected 581 (51.6% males), with a age of 56,8 ± 13,7 years, and basal normal renal function (estimated glomerular filtration rate [e-GFR] calculated by MDRD formula >60/ml/min/1.73m2) and without microalbuminuria (albumin/creatinine ratio <22 mg/gr males and <30 mg/gr females). MS was defined according ATP-III criteria. 310 patients (52%) accomplished for MS criteria and 17 (13%) had type 2 diabetes mellitus. Basal e-GFR was 87.6 ± 18 /ml/min./1.73m2 and basal microalbuminuria 6.5 ± 5.8 mg/gr creatinine. After 4.2 years of follow-up 102 patients (17.3%) developed microalbuminuria: 72 (12.2%) in the group with MS and 30 (5%) in the group without it. 46 patients (7%) developed chronic renal insufficiency: 27 (4, 5%) in whose with MS and 19 (3,2%) in whose without it. In the multivariate analysis the odds ratio (adjusted for age, gender, e-GFR body mass ind...