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dc.contributor.author | Fiuza Luces, María del Carmen | spa |
dc.contributor.author | González-Murillo, África | spa |
dc.contributor.author | Soares-Miranda, Luisa | spa |
dc.contributor.author | Martínez Palacio, Jesús | spa |
dc.contributor.author | Colmenero, Isabel | spa |
dc.contributor.author | Casco Claro, Fernando | spa |
dc.contributor.author | Melén, Gustavo | spa |
dc.contributor.author | Morán, María | spa |
dc.contributor.author | Lucía Mulas, Alejandro | spa |
dc.contributor.author | Ramírez, Manuel | spa |
dc.date.accessioned | 2014-03-18T10:07:03Z | |
dc.date.available | 2014-03-18T10:07:03Z | |
dc.date.issued | 2013 | spa |
dc.identifier.citation | Fiuza-Luces, M. C., González-Murillo, A., Soares-Miranda, L., Martínez-Palacio, J., Colmenero, I., Casco, F., …, & Ramírez, M. (2013). Effects of exercise interventions in graft-versus-host disease models. Cell Transplantation, 22(12), 2409-2420. | spa |
dc.identifier.uri | http://hdl.handle.net/11268/1939 | |
dc.description.abstract | Graft-versus-host-disease (GVHD) is a major complication of allogeneic hematopoietic stem cell transplantation (allo-HSCT), which is associated with high morbimortality and decreased patients' physical capacity. We evaluated the effects of an 11-week moderate-intensity exercise (treadmill) training program performed after allo-HSCT in a murine acute (aGVHD) and chronic GVHD model (cGVHD). Female mice (aged 8–12 weeks) were randomly assigned to the exercise or the control group. They completed a maximal treadmill test before allo-HSCT (with donor bone marrow cells and splenocytes) and after the 11-week period, during which we evaluated clinical severity scores and survival (Kaplan–Meier method). Before allo-HSCT and at days +21, +52 and +83 (upon sacrifice), we collected blood samples for immune cell reconstitution and cytokine analysis. The main results were that (i) in aGVHD, exercise improved maximal physical capacity over the 11-week period compared with pre-allo-HSCT conditions (p < 0.001 for the between-group comparison) and benefited total clinical score evolution (p = 0.05 for the group×time interaction effect), without altering immune reconstitution; (ii) in cGVHD, exercise training resulted in a lesser deterioration of physical capacity after 11 weeks (p = 0.023). Our results highlight the potential beneficial effects of exercise as coadjuvant intervention against GVHD, especially in the acute form of the disease. | spa |
dc.language.iso | eng | spa |
dc.title | Effects of exercise interventions in graft-versus-host disease models | spa |
dc.type | article | spa |
dc.description.impact | 3.570 JCR (2013) Q1, 5/26 Transplantation; Q2, 32/122 Medicine, research & experimental; Q3, 9/18 Cell & tissue engineering | spa |
dc.identifier.doi | 10.3727/096368912X658746 | spa |
dc.rights.accessRights | openAccess | en |
dc.subject.unesco | Deporte | spa |
dc.subject.unesco | Efectos fisiológicos | spa |
dc.subject.unesco | Epidemiología | spa |
dc.description.filiation | UEM | spa |
dc.peerreviewed | Si | spa |