Resumen:
Recurrent aphthous stomatitis (RAS) is a chronic and recurrent inflammatory disease of the mouth. It is characterised by the
appearance of painful ulcers in the oral mucosa. RAS is believed to be a multifactorial disease with genetic predisposition,
environmental factors and alterations in the immune system. Oxidative stress, caused by an imbalance between free radicals
and the antioxidant system, also appears to be involved in the pathogenesis of RAS. Several risk factors, such as smoking,
iron and vitamin deficiency and anxiety, may contribute to the development of the disease. Understanding the underlying
mechanisms may help in the prevention and treatment of RAS. We searched PubMed, Scopus and Web of Science databases
for articles on oxidative stress in patients with RAS from 2000 to 2023. Studies analysing oxidant and antioxidant levels
in the blood and saliva of RAS patients and healthy controls were selected. Of 170 potentially eligible articles, 24 met the
inclusion criteria: 11 studies on blood samples, 6 on salivary samples and 7 on both blood and salivary samples. Multiple
oxidative and antioxidant markers were assessed in blood and saliva samples. Overall, statistically signi...