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dc.contributor.author | Bielza Galindo, Rafael | |
dc.contributor.author | Llorente Gutiérrez, Jesús | |
dc.contributor.author | Thuissard Vasallo, Israel John | |
dc.contributor.author | Andreu Vázquez, Cristina | |
dc.contributor.author | Blanco Díaz, David | |
dc.contributor.author | Sanjurjo Portus, Jorge | |
dc.contributor.author | López Martín, Nestor | |
dc.contributor.author | Herráez García, Regina | |
dc.contributor.author | Molano Ortiz, Cristina | |
dc.contributor.author | Morales Fernández, Adoración | |
dc.contributor.author | Arias Muñana, Estefanía | |
dc.contributor.author | Neira Álvarez, Marta | |
dc.contributor.author | Lung Illes, Ana María | |
dc.contributor.author | Escalera Alonso, Javier | |
dc.contributor.author | Portillo Horcajada, Laura | |
dc.contributor.author | Larrubia Marfil, Yolanda | |
dc.contributor.author | García Fernández, Cristina | |
dc.contributor.author | Zambrana Tevar, Francisco | |
dc.contributor.author | Gómez Cerezo, Jorge Francisco | |
dc.date.accessioned | 2023-03-27T13:00:57Z | |
dc.date.available | 2023-03-27T13:00:57Z | |
dc.date.issued | 2021 | |
dc.identifier.citation | Bielza, R., Llorente, J., Thuissard, I. J., Andreu-Vázquez, C., Blanco, D., Sanjurjo, J., López, N., Herráez, M. R., Molano, C., Morales, A., Arias, E., Neira, M., Lung, A., Escalera, J., Portillo, L., Larrubia, Y., García, C., Zambrana, F., & Gómez Cerezo, J. (2021). Effect of intravenous iron on functional outcomes in hip fracture: a randomised controlled trial. Age and Ageing, 50(1), 127–134. https://doi.org/10.1093/ageing/afaa107 | spa |
dc.identifier.issn | 0002-0729 | |
dc.identifier.issn | 1468-2834 | |
dc.identifier.uri | http://hdl.handle.net/11268/11965 | |
dc.description.abstract | Objectives: to determine the safety and effect of intravenous iron sucrose on functional outcomes, delirium, nosocomial infections and transfusion requirements in older patients with hip fracture. Design: single-centre randomised, double-blind, placebo-controlled clinical trial. Setting and participants: orthogeriatric share care service at an academic tertiary care hospital. A total of 253 patients were recruited: 126 patients were assigned to intravenous iron and 127 to placebo. Methods: on days 1, 3 and 5 after admission, the iron group received 200 mg Venofer® (iron sucrose) in 100 ml saline and the placebo group 100 ml saline. The primary outcome was absolute functional gain, considered as Barthel index (BI) at discharge minus BI on admission. Secondary outcomes included incidence of postoperative delirium according to the confusion assessment method, proportion of patients recovering prior functional status at 3 months, postoperative transfusion requirements, haemoglobin at 3 months, incidence of nosocomial infections and safety. Results: the median participant age was 87 (interquartile range, 82.5-91.5) years. Most patients were female (72.7%), and the median previous BI was 81(59-95). No significant effect of intravenous iron was observed for the primary outcome: the median AFG score was 17.1 points (4.8-23.3) in the intravenous iron group and 16 points (6-26) in the placebo group (P = 0.369). No significant treatment effects were observed for other functional outcomes or secondary end points. Conclusion: while we found no impact of intravenous iron sucrose on functional recovery, incidence of postoperative delirium, transfusion requirements, haemoglobin at 3 months, mortality and nosocomial infections rates in older patients with hip fracture, we did find that the intervention was safe. | spa |
dc.description.sponsorship | Universidad Europea de Madrid (UEM_2016_285) | spa |
dc.language.iso | eng | spa |
dc.subject.other | Fracturas de cadera | spa |
dc.subject.other | Anemia ferropénica | spa |
dc.title | Effect of intravenous iron on functional outcomes in hip fracture: a randomised controlled trial | spa |
dc.type | article | spa |
dc.description.impact | 12.782 Q1 JCR 2021 | spa |
dc.description.impact | 1.750 Q1 SJR 2021 | spa |
dc.description.impact | No data IDR 2021 | spa |
dc.identifier.doi | 10.1093/ageing/afaa107 | |
dc.rights.accessRights | openAccess | spa |
dc.subject.unesco | Gerontología | spa |
dc.subject.unesco | Enfermedad nutricional | spa |
dc.subject.unesco | Tratamiento médico | spa |
dc.description.filiation | UEM | spa |
dc.relation.publisherversion | https://doi.org/10.1093/ageing/afaa107 | spa |
dc.peerreviewed | Si | spa |
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