QuantiFERON-TB Gold Plus Assay Specificity in Children and Adolescents With Suspected Tuberculosis-A Multicenter Cross-sectional Study in Spain

Soler García, Aleix; Gamell, Anna; Santiago, Begoña; Monsonís, Manuel; Cobo Vázquez, Elvira; Bustillo Alonso, Matilde; Tagarro García, Alfredo; Pérez Gorricho, Beatriz; Espiau, María; QFT-Plus Study Group of the Spanish Pediatric TB Research Network; Et al.

doi:10.1097/INF.0000000000003173

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QuantiFERON-TB Gold Plus Assay Specificity in Children and Adolescents With Suspected Tuberculosis-A Multicenter Cross-sectional Study in Spain

Soler García, Aleix; Gamell, Anna; Santiago, Begoña; Monsonís, Manuel; Cobo Vázquez, Elvira; Bustillo Alonso, Matilde; Tagarro García, Alfredo; Pérez Gorricho, Beatriz; Espiau, María; QFT-Plus Study Group of the Spanish Pediatric TB Research Network; Et al.

Use este identificador para citar o enlazar este ítem: http://hdl.handle.net/11268/11468

Fecha: 2021

Materia UNESCO: Aparato respiratorio
Materia UNESCO: Enfermedad
Materia UNESCO: Medicina preventiva

Tipo: article

Versión del editor: https://doi.org/10.1097/INF.0000000000003173

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Resumen:

In this cross-sectional study of 284 children and adolescents with clinically or radiologically suspected tuberculosis in a low-endemic country, the QuantiFERON-TB Gold Plus assay specificity, sensitivity, positive predictive value and negative predictive value were 91.5%, 87.3%, 86.4%, and 91.2%, respectively. The specificity was higher than that observed in tuberculin skin tests performed simultaneously, but similar to previous-generation interferon-gamma release assays.

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