Resumen:
Skin toxicity is one of paclitaxel’s adverse effects. However, its real impact on the
skin could be underestimated as these alterations can also appear asymptomatic. We have observed
that paclitaxel modifies gene and protein expression of skin markers in a 3D epidermis model, and
impairs physical, physiological, and biomechanical properties of the skin in gynecologic cancer
patients. These subclinical alterations might be avoided by using prophylactic measures during
treatment to prevent possible future adverse reactions.