Elevated linezolid resistance in clinical cfr-positive Staphylococcus aureus isolates is associated with co-occurring mutations in ribosomal protein L3

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dc.contributor.authorLocke, Jeffrey B.spa
dc.contributor.authorMorales Kucharski, María Graciaspa
dc.contributor.authorHilgers, Markspa
dc.contributor.authorKedar, G. C.spa
dc.contributor.authorRahawi, Shahadspa
dc.contributor.authorPicazo, Juan Joséspa
dc.contributor.authorShaw, Karen Joyspa
dc.contributor.authorStein, Jeffrey L.spa
dc.date.accessioned2013-11-27T17:26:49Z
dc.date.available2013-11-27T17:26:49Z
dc.date.issued2010spa
dc.description.abstractResistance to linezolid (LZD) occurs through mutations in 23S rRNA and ribosomal proteins L3 and L4 or through methylation of 23S rRNA by Cfr. Here we report novel L3 mutations, ΔSer145/His146Tyr and ΔMet169-Gly174, co-occurring with <I>cfr</I> in LZD-resistant <I>Staphylococcus aureus</I> isolates recovered from a hospital outbreak in Madrid, Spain. LZD MIC values (16, 32, or 64 μg/ml) correlated with the presence and severity of the L3 mutation. All isolates had TR-700 (torezolid) MIC values of ≤2 μg/ml.spa
dc.description.impact4.672 JCR (2010) Q1, 18/107 Microbiology, 26/252 Pharmacology & pharmacyspa
dc.identifier.citationLocke, J. B., Morales, G., Hilgers, M., Kedar, G. C., Rahawi, S., Picazo, J. J., ..., & Stein, J. L. (2010). Elevated linezolid resistance in clinical cfr-positive Staphylococcus aureus isolates is associated with co-occurring mutations in ribosomal protein L3. Antimicrobial Agents and Chemotherapy, 54(12), 5352-5355.spa
dc.identifier.doi10.1128/AAC.00714-10spa
dc.identifier.urihttp://hdl.handle.net/11268/1075
dc.language.isoengspa
dc.peerreviewedSispa
dc.rights.accessRightsopen accessen
dc.subject.unescoMicrobiologíaspa
dc.subject.unescoBacteriologíaspa
dc.titleElevated linezolid resistance in clinical cfr-positive Staphylococcus aureus isolates is associated with co-occurring mutations in ribosomal protein L3spa
dc.typejournal articlespa
dspace.entity.typePublication

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