Distinct NK cell function and gene expression in children with acute lymphoblastic leukemia in remission before and after acute exercise: an exploratory stud

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dc.contributor.authorPlaza Florido, Abel
dc.contributor.authorPerlsteyn, Martin
dc.contributor.authorHaddad, Fadia
dc.contributor.authorCooper, Dan M.
dc.contributor.authorBar Yoseph, Ronen
dc.contributor.authorLucía Mulas, Alejandro
dc.contributor.authorRadom Aizik, Shlomit
dc.date.accessioned2026-07-24T15:35:42Z
dc.date.available2026-07-24T15:35:42Z
dc.date.issued2025
dc.description.abstractBrief bouts of exercise mobilize natural killer (NK) cells and influence their function and gene expression in adults. However, little is known about these effects in children with acute lymphoblastic leukemia (ALL) in remission. This study investigated the effect of acute exercise on NK gene expression and cytotoxic activity (NKCA) in children with ALL in remission. Acute exercise may improve NK cell function in ALL children in remission and has the potential to be used as adjunctive therapy in ALL. The differential gene expression response to exercise suggests that NK cells in ALL may adopt a different molecular strategy to fight infections or tumors.en
dc.description.filiationUEMspa
dc.description.impact7.0 Q1 JCR 2025
dc.description.impact1.964 Q1 SJR 2025
dc.description.impactNo data IDR 2024
dc.description.sponsorshipAyuda de la Facultad de Medicina de UC Irvine —UC Irvine School of Medicine Faculty Grant— otorgada a Shlomit Radom Aizik.es
dc.description.sponsorshipFinanciado por la subvención de los National Institutes of Health (NIH) n.º U01 TR002004 (proyecto REACH).es
dc.description.sponsorshipAcceso al recurso Genomics Research and Technology Hub —anteriormente Genomics High-Throughput Facility—, recurso compartido del Cancer Center Support Grant (P30CA-062203).es
dc.description.sponsorshipAcceso al recurso compartido Single Cell Analysis Core de Complexity, Cooperation and Community in Cancer (U54CA217378).es
dc.description.sponsorshipAcceso al recurso Genomics-Bioinformatics Core del Skin Biology Resource Based Center @ UCI (P30AR075047) de la University of California Irvine.es
dc.description.sponsorshipFinanciado por las subvenciones de instrumentación compartida de los NIH 1S10OD010794-01 (PacBio RS) y 1S10OD021718-01 (HiSeq 4000).es
dc.description.sponsorshipLa investigación de Alejandro Lucía está financiada por Wereld Kanker Onderzoek Fonds (WKOF) como parte del programa de subvenciones World Cancer Research Fund International (IIG_FULL_2021_007).es
dc.identifier.citationPlaza-Florido, A., Perlsteyn, M., Haddad, F., Cooper, D. M., Bar-Yoseph, R., Lucia, A., & Radom-Aizik, S. (2025). Distinct NK cell function and gene expression in children with acute lymphoblastic leukemia in remission before and after acute exercise: An exploratory study. Frontiers in Immunology, 16, 1625437. https://doi.org/10.3389/fimmu.2025.1625437
dc.identifier.doi10.3389/FIMMU.2025.1625437
dc.identifier.issn1664-3224
dc.identifier.urihttps://hdl.handle.net/11268/17319
dc.language.isoeng
dc.peerreviewedSi
dc.relation.publisherversionhttps://doi.org/10.3389/FIMMU.2025.1625437
dc.rightsAttribution 4.0 Internationalen
dc.rights.accessRightsopen access
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subject.otherCiencias del Deporte
dc.subject.otherLeucemia-Linfoma Linfoblástico de Células Precursoras
dc.subject.otherCélulas Asesinas Naturales
dc.subject.otherEjercicio Físico
dc.subject.sdgGoal 3: Ensure healthy lives and promote well-being for all at all ages
dc.subject.unescoCiencias médicas
dc.subject.unescoInmunología
dc.subject.unescoCáncer
dc.titleDistinct NK cell function and gene expression in children with acute lymphoblastic leukemia in remission before and after acute exercise: an exploratory studen
dc.typejournal article
dc.type.hasVersionVoR
dspace.entity.typePublication
relation.isAuthorOfPublicationd3691359-d7bd-4a12-b84e-338e28c81f9f
relation.isAuthorOfPublication.latestForDiscoveryd3691359-d7bd-4a12-b84e-338e28c81f9f

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