Magnetoencephalographic Signatures of Facial Emotion Processing in Schizophrenia and Major Depressive Disorder: A Systematic Review

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Scala, Mauro
Dukart, Juergen
Simone, Giuseppe de
Fanelli, Giuseppe
Arroyo Iturra, Rocío

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SDG

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Social withdrawal is a frequent marker of functional decline in schizophrenia, Alzheimer’s disease (AD), and major depressive disorder (MDD), and is associated with deficits in facial-emotion recognition (FER). Magnetoencephalography (MEG) captures neuronal activity at millisecond resolution, enabling the assessment of fast oscillatory dynamics and functional connectivity during FER. This systematic review compares MEG responses during implicit and explicit FER tasks in adults with schizophrenia, AD, and MDD to identify possible transdiagnostic and disorder-specific alterations.

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Scala, M., Dukart, J., De Simone, G., Fanelli, G., Arroyo Iturra, R., Bordignon, S., Fabbri, C., & Serretti, A. (2026). Magnetoencephalographic signatures of facial emotion processing in schizophrenia and major depressive disorder: A systematic review. Neuropsychobiology, 1-21. https://doi.org/10.1159/000550903

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