Association between fat-free mass and lipid profile and cardiovascular risk indices in women with systemic lupus erythematosus: a multicenter cross-sectional study

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dc.contributor.authorMota, Jhulia Caroline Nunes Leal da
dc.contributor.authorSmaira, Fabiana I.
dc.contributor.authorGualano, Bruno
dc.contributor.authorCruz Mosso, Ulises De la
dc.contributor.authorCampos López, Bertha
dc.contributor.authorMora García, Paulina E.
dc.contributor.authorPesqueda Cendejas, Karen
dc.contributor.authorHiguera Gómez, Andrea
dc.contributor.authorCuevas Sierra, Amanda
dc.contributor.authorMartínez, J. Alfredo
dc.contributor.authoret al.
dc.date.accessioned2026-09-03T16:31:08Z
dc.date.available2026-09-03T16:31:08Z
dc.date.issued2026
dc.description.abstractWomen with systemic lupus erythematosus (SLE) exhibit increased cardiovascular risk, partly explained by adverse fat distribution. This multicenter cross-sectional study investigated whether fat-free mass (FFM) is independently related to lipid metabolism and cardiovascular risk and identified metabolic clusters combining body composition and lipid parameters in women with SLE from an Ibero-American cohort. In women with SLE, greater fat-free mass was associated with a more favorable lipid profile and selected atherogenic indices, independent of demographic and disease-related factors. Although causality cannot be inferred due to the cross-sectional design, these findings suggest that lean mass may represent an important component of cardiometabolic health in SLE.en
dc.description.filiationUEM
dc.description.impact3.6 Q2 JCR 2025
dc.description.impact0.954 Q2 SJR 2025
dc.description.impactNo data IDR 2024
dc.description.sponsorshipFinanciado por la Fundación de Apoyo a la Investigación del Estado de São Paulo (FAPESP) mediante las ayudas n.º 2020/01893-2, 2020/15126-3, 2024/03408-5 y 2019/14819-8.es
dc.description.sponsorshipEste trabajo recibió financiación del proyecto Metacategorización personalizada de los procesos inflamatorios asociados al síndrome metabólico, las enfermedades autoinmunes y las enfermedades virales para una medicina de precisión (METAINFLAMACIÓN, Ref.: Y2020/BIO-6600), financiado por la Comunidad de Madrid (España).es
dc.identifier.citationDa Mota, J. C., Smaira, F. I., Gualano, B., Mosso, U. D. L. C., Campos-López, B., Mora-García, P. E., Pesqueda-Cendejas, K., Meza, M. R. M., Vizmanos, B., Higuera-Gómez, A., De Cuevillas, B., Cuevas-Sierra, A., Martínez-Urbistondo, M., Martinez, J. A., & Nicoletti, C. F. (2026). Association between fat-free mass, lipid profile and cardiovascular risk indices in women with systemic lupus erythematosus: A multicenter cross-sectional study. Nutrition, 151, 113333. https://doi.org/10.1016/j.nut.2026.113333
dc.identifier.doi10.1016/j.nut.2026.113333
dc.identifier.issn0899-9007
dc.identifier.issn1873-1244
dc.identifier.urihttps://hdl.handle.net/11268/17399
dc.language.isoeng
dc.peerreviewedSi
dc.relation.publisherversionhttps://doi.org/10.1016/j.nut.2026.113333
dc.rightsAttribution 4.0 Internationalen
dc.rights.accessRightsopen access
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subject.otherFarmacia y nutrición
dc.subject.otherLupus Eritematoso Sistémico
dc.subject.otherDislipidemias
dc.subject.otherEnfermedades Cardiovasculares
dc.subject.sdgGoal 3: Ensure healthy lives and promote well-being for all at all ages
dc.subject.unescoCiencias médicas
dc.subject.unescoMedicina clínica
dc.subject.unescoNutrición
dc.titleAssociation between fat-free mass and lipid profile and cardiovascular risk indices in women with systemic lupus erythematosus: a multicenter cross-sectional studyen
dc.typejournal article
dc.type.hasVersionVoR
dspace.entity.typePublication

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