Sex-specific modulation of T-type voltage-gated calcium channels in the renal artery of hypertensive rats

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dc.contributor.authorSuarez, Andrea
dc.contributor.authorGuerra Ojeda, Sol
dc.contributor.authorValls, Alicia
dc.contributor.authorVerdú, David
dc.contributor.authorSerna García, Marta
dc.contributor.authorHerrera, Guadalupe
dc.contributor.authorSerna, Eva
dc.contributor.authorMauricio, María Dolores
dc.date.accessioned2026-05-15T10:41:12Z
dc.date.available2026-05-15T10:41:12Z
dc.date.issued2026
dc.description.abstractHypertension contributes to cardiovascular disease, with growing evidence of sex-specific differences in its underlying mechanisms. T-type voltage-gated calcium channels (VGCCs) have emerged as key regulators of vascular tone, particularly under conditions of nitric oxide (NO) deficiency. However, their role in mediating vascular dysfunction across sexes remains poorly understood. This study examines the role of T-type VGCCs and their modulation by NO in the renal artery of male and female spontaneously hypertensive rats (SHR).en
dc.description.filiationUEV
dc.description.impact3.5 Q1 JCR 2024
dc.description.impact1.065 Q2 SJR 2025
dc.description.impactNo data IDR 2024
dc.description.sponsorshipCIAICO 2023/013es
dc.description.sponsorshipCIAPOS 2023/276es
dc.identifier.citationSuarez, A., Guerra-Ojeda, S., Valls, A., Verdú, D., Serna-García, M., Herrera, G., Serna, E., & Mauricio, M. D. (2026). Sex-specific modulation of T-type voltage-gated calcium channels in the renal artery of hypertensive rats. Frontiers in Physiology, 17, 1754344. https://doi.org/10.3389/fphys.2026.1754344
dc.identifier.doi10.3389/fphys.2026.1754344
dc.identifier.issn1664-042X
dc.identifier.urihttps://hdl.handle.net/11268/17095
dc.language.isoeng
dc.peerreviewedSi
dc.relation.publisherversionhttps://doi.org/10.3389/fphys.2026.1754344
dc.rightsAttribution 4.0 Internationalen
dc.rights.accessRightsopen access
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subject.otherBiociencias
dc.subject.otherÓxido nítrico
dc.subject.otherArteria renal
dc.subject.otherDiferencias sexuales
dc.subject.sdgGoal 3: Ensure healthy lives and promote well-being for all at all ages
dc.subject.unescoSistema cardiovascular
dc.subject.unescoEnfermedad cardiovascular
dc.subject.unescoMedicina preventiva
dc.titleSex-specific modulation of T-type voltage-gated calcium channels in the renal artery of hypertensive rats
dc.typejournal article
dc.type.hasVersionVoR
dspace.entity.typePublication

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