Streptococcus dentisani as an oral probiotic: a systematic review of clinical evidence on the pH modulation and microbiota shifts

Abstract

Dental caries prevention can be approached through ecological modulation of the oral biofilm. Among oral probiotics, Streptococcus dentisani stands out for its arginine deiminase (ADI) pathway, producing ammonia with an alkalinizing effect, and for bacteriocins active against cariogenic organisms, suggesting restoration of acid–base homeostasis and displacement of dysbiosis-associated taxa. This study aims to systematically review clinical evidence on S. dentisani and other probiotics regarding their effects on pH modulation and oral microbiota shifts.