Tumour SNPs associated with immune‑related hepatitis in patients with melanoma receiving immune checkpoint inhibitors

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dc.contributor.authorRodríguez Piñas, José María
dc.contributor.authorRomero Lorca, Alicia
dc.contributor.authorGaibar Alonso, María
dc.contributor.authorNovillo Villajos, Apolonia
dc.contributor.authorRubio Alonso, Margarita
dc.contributor.authorMalón, Diego
dc.contributor.authorAntón Pascual, Beatriz
dc.contributor.authorCamacho Castañeda, Francisca Inmaculada
dc.contributor.authorCavanagh, Mercedes
dc.contributor.authorLuján Rodríguez, David Ricardo
dc.contributor.authoret al.
dc.date.accessioned2025-10-21T15:38:18Z
dc.date.available2025-10-21T15:38:18Z
dc.date.issued2025
dc.description.abstractImmune checkpoint inhibitors (ICIs) have significantly improved survival rates for patients with metastatic melanoma. However, these treatments can lead to immune-related adverse events (irAEs), including hepatitis. This exploratory study sought to identify tumour single-nucleotide polymorphisms (SNPs) associated with the risk of ICI-induced hepatitis in melanomapatients. This exploratory study identifies candidate tumour SNPs as possible biomarkers to predict the risk of ICI-induced hepatitis, warranting their validation in larger patient cohorts.
dc.description.filiationUEM
dc.description.impact3.9 Q1 JCR 2024
dc.description.impact1.114 Q1 SJR 2024
dc.description.impactNo data IDR 2023
dc.description.sponsorshipUniversidad Europea de Madrid (subvención 2022/UEM19).
dc.identifier.citationJose María Rodríguez-Piñas, Alicia Romero-Lorca, María Gaibar, Apolonia Novillo, Margarita Rubio, Diego Malon, Beatriz Antón-Pascual, Francisca Inmaculada Camacho, Mercedes Cavanagh, David Ricardo Lujan Rodriguez, Ana Manuela Martín, Radia Khedaoui, Diana Moreno, Fernando Javier Pinedo, Macarena Boiza, Silvia García, Patricia Gómez, David Marrupe, Ana Fernández-Santander. Tumour SNPs associated with immune‑related hepatitis in patients with melanoma receiving immune checkpoint inhibitors. (2025). Biomedicines. 13(10), 2351. https://doi.org/10.3390/biomedicines13102351
dc.identifier.doi10.3390/biomedicines13102351
dc.identifier.issn2227-9059
dc.identifier.urihttps://hdl.handle.net/11268/16410
dc.language.isoeng
dc.peerreviewedSi
dc.relation.publisherversionhttp://doi.org/10.3390/biomedicines13102351
dc.rightsAttribution 4.0 Internationalen
dc.rights.accessRightsopen access
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subject.otherHepatitis
dc.subject.otherPolimorfismo de Nucleótido Simple
dc.subject.otherMelanoma
dc.subject.sdgGoal 3: Ensure healthy lives and promote well-being for all at all ages
dc.subject.sdgGoal 4: Quality education
dc.subject.sdgGoal 9: Build resilient infrastructure, promote sustainable industrialization and foster innovation
dc.subject.unescoCiencias médicas
dc.subject.unescoGenética humana
dc.subject.unescoMedicina clínica
dc.titleTumour SNPs associated with immune‑related hepatitis in patients with melanoma receiving immune checkpoint inhibitors
dc.typejournal article
dc.type.hasVersionVoR
dspace.entity.typePublication
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relation.isAuthorOfPublication.latestForDiscovery6df66eed-0c97-49a7-87e4-7052fb851239

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