Relevance of loss of heterozigosity in chromosome 3p in non small cell lung carcinoma as prognostic factor

Abstract

Recent advances on carcinogenesis have led to the recognition of different patterns of behaviour of non-small cell lung cancers appart from those guided by the TNM staging system and the histologic subtype. The frequent genetic loss on chromosome 3p in all kinds of lung carcinoma leads to the suspect of the presence of a tumor suppresor gene located in that place. The aim of this work was to compare the different clinical features and evolution after treatment of the patients with non small cell lung carcinoma with and without loss of heterozigosity (LOH) on 3p.