Evaluation of the Impact of Elexacaftor/Tezacaftor/Ivacaftor on Aerobic Capacity in Children With Cystic Fibrosis Aged 6–11 Years: Actual Observations and Clinical Perspectives.
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Bos, Mats te
Fernández García, Patricia
Manuel, Cristina de
Morales Tirado, Ana
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Abstract
Cystic fibrosis causes exercise limitation due to impaired lung function and other complications, which in turn increases the chance of mortality. CFTR modulators, particularly the elexacaftor/tezacaftor/ivacaftor (ETI) combination, improve lung function in children older than 6 years in real-life studies.
This study aimed to assess the impact of ETI on aerobic capacity in children with CF aged 6–11 years under real-life conditions and to evaluate whether prior CFTR modulator treatment affects these outcomes.
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Pérez-Ruiz, M., Te Bos, M., Fernández-García, P., Manuel, C. D., Morales-Tirado, A., López-Neyra, A., Valbuena, M. R. D., Rubio, M., & Sanz-Santiago, V. (2025). Evaluation of the impact of elexacaftor/tezacaftor/ivacaftor on aerobic capacity in children with cystic fibrosis aged 6–11 years: Actual observations and clinical perspectives. Archivos de Bronconeumología, S0300289625000717. https://doi.org/10.1016/j.arbres.2025.02.010