Cardiovascular Safety of Anagrelide in Healthy Subjects: Effects of Caffeine and Food Intake on Pharmacokinetics and Adverse Reactions

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dc.contributor.authorMartínez Sellés Oliveria Soares, Manuel
dc.contributor.authorDatino Romaniega, Tomás
dc.contributor.authorFigueiras-Graillet, Lourdesspa
dc.contributor.authorGama, Joubert G.spa
dc.contributor.authorJones, Christopherspa
dc.contributor.authorFranklin, Richardspa
dc.contributor.authorFernández-Avilés, Franciscospa
dc.date.accessioned2013-11-27T17:26:50Z
dc.date.available2013-11-27T17:26:50Z
dc.date.issued2013spa
dc.description.abstractEssential thrombocythaemia (ET) is a rare clonal myeloproliferative disorder characterized by a sustained elevation in platelet count and megakaryocyte hyperplasia. Anagrelide is used in the treatment of ET, where it has been shown to reduce platelet count. Anagrelide is metabolized by cytochrome P450 (CYP) 1A2, and previous studies of the effect of food on the bioavailability and pharmacokinetics of anagrelide were conducted prior to the identification of the active metabolite, 3-hydroxyanagrelide.spa
dc.description.impact1.704 JCR (2013) Q3, 167/254 Pharmacology & pharmacyspa
dc.identifier.citationMartínez-Sellés, M., Datino, T., Figueiras-Graillet, L., Gama, J. G., Jones, C., Franklin, R., & Fernández-Avilés, F. (2013). Cardiovascular safety of anagrelide in healthy subjects: effects of caffeine and food intake on pharmacokinetics and adverse reactions. Clinical Drug Investigation, 33(1), 45-54.spa
dc.identifier.doi10.1007/s40261-012-0032-2spa
dc.identifier.urihttp://hdl.handle.net/11268/1087
dc.language.isoengspa
dc.peerreviewedSispa
dc.rights.accessRightsrestricted accessen
dc.subject.unescoEnfermedad cardiovascularspa
dc.subject.unescoFarmacologíaspa
dc.subject.unescoDietéticaspa
dc.titleCardiovascular Safety of Anagrelide in Healthy Subjects: Effects of Caffeine and Food Intake on Pharmacokinetics and Adverse Reactionsspa
dc.typejournal articlespa
dspace.entity.typePublication
relation.isAuthorOfPublicationa14a4cbe-6878-47e7-8b7b-ffdd4a82573a
relation.isAuthorOfPublication3b921248-7bff-46a5-82dc-d34204d9f6b0
relation.isAuthorOfPublication.latestForDiscoverya14a4cbe-6878-47e7-8b7b-ffdd4a82573a

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