PI3K/mTOR inhibition attenuates cigarette smoke-induced senescence and SASP in oral fibroblasts: implications for tumor microenvironment remodeling

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dc.contributor.authorFlacco, Nicla
dc.contributor.authorEstornut Navarro, Cristina
dc.contributor.authorRoger Laparra, Inés
dc.contributor.authorRibera, Pilar
dc.contributor.authorSánchez Herrera, Germán
dc.contributor.authorTrujillo Barberá, Silvia
dc.contributor.authorPérez Leal, Martín
dc.date.accessioned2026-05-02T10:23:11Z
dc.date.available2026-05-02T10:23:11Z
dc.date.issued2026
dc.description.abstractCigarette smoke exposure is a major risk factor for oral cancer, partly due to its ability to induce early molecular alterations in the oral mucosa. Cellular senescence and the senescence-associated secretory phenotype (SASP) contribute to chronic inflammation and microenvironmental remodeling, favoring carcinogenesis. The PI3K/AKT/mTOR pathway has been implicated in sustaining SASP and senescence, suggesting that its inhibition may represent a promising preventive strategy.en
dc.description.filiationUEV
dc.description.impact4.3 Q2 JCR 2024
dc.description.impact1.563 Q1 SJR 2025
dc.description.impactNo data IDR 2024
dc.description.sponsorshipCátedra ASISA - Universidad Europea. 2023/01CAes
dc.identifier.citationFlacco, N., Estornut, C., Roger, I., Ribera, P., Sánchez-Herrera, G., Trujillo-Barbera, S., & Pérez-Leal, M. (2026). PI3K/mTOR inhibition attenuates cigarette smoke-induced senescence and SASP in oral fibroblasts: Implications for tumor microenvironment remodeling. Frontiers in Cell and Developmental Biology, 14, 1745944. https://doi.org/10.3389/fcell.2026.1745944
dc.identifier.doi10.3389/fcell.2026.1745944
dc.identifier.issn2296-634X
dc.identifier.urihttps://hdl.handle.net/11268/17064
dc.language.isoeng
dc.peerreviewedSi
dc.relation.publisherversionhttps://doi.org/10.3389/fcell.2026.1745944
dc.rightsAttribution 4.0 Internationalen
dc.rights.accessRightsopen access
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subject.otherBiociencias
dc.subject.otherFibroblastos
dc.subject.otherFenotipo secretor asociado a la senescencia
dc.subject.otherMicroambiente tumoral
dc.subject.sdgGoal 3: Ensure healthy lives and promote well-being for all at all ages
dc.subject.unescoTabaquismo
dc.subject.unescoInvestigación médica
dc.subject.unescoMedicina preventiva
dc.titlePI3K/mTOR inhibition attenuates cigarette smoke-induced senescence and SASP in oral fibroblasts: implications for tumor microenvironment remodeling
dc.typejournal article
dc.type.hasVersionVoR
dspace.entity.typePublication

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