Even at 100+: Acute Exercise Modulates Inflammatory Pathways in Centenarians

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URI: https://hdl.handle.net/11268/17334
DOI: 10.1111/ACEL.70152

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2025

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Plaza Florido, Abel
Pérez Prieto, Inmaculada
Carrera Bastos, Pedro

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SDG

goal-3

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Abstract

Centenarians exhibit remarkable disease resilience despite chronic low-grade inflammation. We investigated the inflammation-related proteome response to acute exercise in seven centenarians (100–104 years). Exercise downregulated 52 proteins (e.g., TNF, IL10, IL1RN, CCL family members) involved in immune cell trafficking, apoptosis, and cytokine regulation. Even at the extreme end of the lifespan, humans retain molecular responsiveness to exercise, with modulation of inflammation-related pathways.

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Ciencias médicas
Gerontología
Inmunología

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Plaza‐Florido, A., Alejo, L. B., Pérez‐Prieto, I., Carrera‐Bastos, P., Muñoz, M. R., Aldazabal, I. P., Barranco‐Gil, D., Santos‐Lozano, A., Rodríguez‐Romo, G., Yanguas‐Casás, N., Radom‐Aizik, S., Lucia, A., & Fiuza‐Luces, C. (2025). Even at 100+: Acute exercise modulates inflammatory pathways in centenarians. Aging Cell, 24(9), e70152. https://doi.org/10.1111/acel.70152
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https://doi.org/10.1111/ACEL.70152

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journal article

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Área de Ciencias de la Salud
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