Pharmacokinetics and pharmacodynamics of valganciclovir in infants with severe HIV-associated pneumonia in Africa: a sub-study of the EMPIRICAL randomised controlled trial

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dc.contributor.authorJacobs, Tom G.
dc.contributor.authorMumbiro, Vivian
dc.contributor.authorTembo, John
dc.contributor.authorEgbe, Franklin N.
dc.contributor.authorMoraleda, Cinta
dc.contributor.authordos Anjos Botas Beca, Laize Silvia
dc.contributor.authorPassanduca, Alfeu
dc.contributor.authorKakooza, Lawrence
dc.contributor.authorDomínguez Rodríguez, Sara
dc.date.accessioned2026-10-26T17:06:35Z
dc.date.available2026-10-26T17:06:35Z
dc.date.issued2026-04-13
dc.description.abstractCytomegalovirus (CMV) is a major unrecognised cause of morbidity and mortality in infants living with HIV. Valganciclovir, an oral prodrug of ganciclovir, treats CMV in immunocompromised patients, but pharmacokinetic data in infants living with HIV are lacking. This study evaluated exploratory valganciclovir pharmacokinetic and pharmacodynamic outcomes in infants with severe HIV-associated pneumonia.en
dc.description.filiationUEMspa
dc.description.impact12.8 Q1 JCR 2025
dc.description.impact4.171 Q1 SJR 2025
dc.description.impactNo data IDR 2025
dc.description.sponsorshipEuropean and Developing Countries Clinical Trials Partnership - EDCTP2
dc.identifier.citationJacobs, T. G., Mumbiro, V., Tembo, J., Egbe, F. N., Moraleda, C., Beca, L. S. D. A. B., Passanduca, A., Kakooza, L., Chitsamatanga, M., Nduna, B., Bramugy, J., Tagarro, A., Chhaganlal, K. D., Mutesi, S., Mark, N. L., Bwakura-Dangarembizi, M., Namuzizya, N., Ballesteros, A., Dominguez-Rodríguez, S., … Manukyan, L. (2026). Pharmacokinetics and pharmacodynamics of valganciclovir in infants with severe HIV-associated pneumonia in Africa: A sub-study of the EMPIRICAL randomised controlled trial. eClinicalMedicine, 94, 103899. https://doi.org/10.1016/j.eclinm.2026.103899
dc.identifier.doi10.1016/j.eclinm.2026.103899
dc.identifier.issn2589-5370
dc.identifier.urihttps://hdl.handle.net/11268/17512
dc.language.isoeng
dc.peerreviewedSi
dc.relation.publisherversionhttps://doi.org/10.1016/j.eclinm.2026.103899
dc.rightsAttribution 4.0 Internationalen
dc.rights.accessRightsopen access
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subject.otherBiociencias
dc.subject.sdgGoal 3: Ensure healthy lives and promote well-being for all at all ages
dc.subject.unescoVirología
dc.subject.unescoInmunología
dc.subject.unescoPediatría
dc.titlePharmacokinetics and pharmacodynamics of valganciclovir in infants with severe HIV-associated pneumonia in Africa: a sub-study of the EMPIRICAL randomised controlled trialen
dc.typejournal article
dc.type.hasVersionVoR
dspace.entity.typePublication

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