The cardiovascular risk marker itaconate is sex-dependently associated with legume intake and immune-inflammatory competence in subjects with high BMI

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dc.contributor.authorCuevas Sierra, Amanda
dc.contributor.authorHiguera Gómez, Andrea
dc.contributor.authorCuevillas, Begoña de
dc.contributor.authorPaula Buestan, Gabriela
dc.contributor.authorMartínez Urbistondo, María
dc.contributor.authorCastejón, Raquel
dc.contributor.authorVargas, J. Antonio
dc.contributor.authorLaparra, José Moisés
dc.contributor.authorMartínez, J. Alfredo
dc.date.accessioned2026-06-03T14:18:49Z
dc.date.available2026-06-03T14:18:49Z
dc.date.issued2026
dc.description.abstractItaconate has received attention as a key immunometabolic mediator produced by activated macrophages, linking cellular metabolism to inflammatory responses. The aim of this investigation is to analyze the determinants of circulating itaconate concentrations involving metabolic associations, with markers of innate immune activation and systemic inflammation, as well as to evaluate the potential modulatory role of dietary patterns—particularly legume consumption—as well as sex-specific differences concerning these relationships in subjects with excessive adiposity.en
dc.description.filiationUEM
dc.description.impact5.9 Q1 JCR 2024
dc.description.impact1.964 Q1 SJR 2025
dc.description.impactNo data IDR 2024
dc.description.sponsorshipMETAINFLAMACIÓN (Y2020/BIO-6600)es
dc.description.sponsorshipTEC-2024/BIO-307_BICAROBESITY-CMes
dc.description.sponsorshipInstituto de Salud Carlos III Miguel Servet (CP25/00072)es
dc.identifier.citationCuevas-Sierra, A., Higuera-Gómez, A., De Cuevillas, B., Paula-Buestan, G., Martínez-Urbistondo, M., Castejón, R., Vargas, J. A., Laparra, J. M., & Martínez, J. A. (2026). The cardiovascular risk marker itaconate is sex-dependently associated with legume intake and immune-inflammatory competence in subjects with high BMI. Frontiers in Immunology, 17, 1853371. https://doi.org/10.3389/fimmu.2026.1853371
dc.identifier.doi10.3389/fimmu.2026.1853371
dc.identifier.issn1664-3224
dc.identifier.urihttps://hdl.handle.net/11268/17133
dc.language.isoeng
dc.peerreviewedSi
dc.relation.publisherversionhttps://doi.org/10.3389/fimmu.2026.1853371
dc.rightsAttribution 4.0 Internationalen
dc.rights.accessRightsopen access
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subject.otherFarmacia y nutrición
dc.subject.otherMonocitis
dc.subject.otherFactores de riesgo
dc.subject.otherEnfermedades cardiovasculares
dc.subject.sdgGoal 3: Ensure healthy lives and promote well-being for all at all ages
dc.subject.unescoEnfermedad cardiovascular
dc.subject.unescoMetabolismo
dc.subject.unescoMedicina preventiva
dc.titleThe cardiovascular risk marker itaconate is sex-dependently associated with legume intake and immune-inflammatory competence in subjects with high BMI
dc.typejournal article
dc.type.hasVersionVoR
dspace.entity.typePublication

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