Amyloid-β and tau pathology induce a reduction of the G-protein Gαo subunit in the mouse hippocampus

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dc.contributor.authorAguado, Carolina
dc.contributor.authorMartínez Poyato, María Llanos
dc.contributor.authorMartín Belmonte, Alejandro
dc.contributor.authorAlfaro Ruiz, Rocío
dc.contributor.authorMoreno Martínez, Ana Esther
dc.contributor.authorLuján, Rafael
dc.date.accessioned2026-03-17T15:48:31Z
dc.date.available2026-03-17T15:48:31Z
dc.date.issued2026
dc.description.abstractHeterotrimeric guanine nucleotide-binding proteins (G-proteins) transmit signals from G protein-coupled receptors (GPCRs) to intracellular effector systems that are disrupted in Alzheimer’s disease (AD). However, there is limited information on the specific changes in Gα subunits related to amyloidosis and tauopathy at the subcellular level. This study aimes to detect potential alterations in the protein levels and localization of Gαo in the brains of 5xFAD, APP/PS1, and P301S mice using histoblot and quantitative immunoelectron microscopic techniques.en
dc.description.filiationUEV
dc.description.impact2.5 Q1 JCR 2024
dc.description.impact0.677 Q2 SJR 2024
dc.description.impactNo data IDR 2024
dc.description.sponsorshipPID2024–155887OB-I00es
dc.description.sponsorshipPID2021–125875OB-I00es
dc.description.sponsorshipUniversidad de Castilla-La Mancha 2025-GRIN-38362es
dc.identifier.citationAguado, C., Martínez-Poyato, M. D. L. L., Martín-Belmonte, A., Alfaro-Ruiz, R., Moreno-Martínez, A. E., & Luján, R. (2026). Amyloid-β and tau pathology induce a reduction of the G-protein Gαo subunit in the mouse hippocampus. Tissue and Cell, 101, 103436. https://doi.org/10.1016/j.tice.2026.103436
dc.identifier.doi10.1016/j.tice.2026.103436
dc.identifier.issn0040-8166
dc.identifier.issn1532-3072
dc.identifier.urihttps://hdl.handle.net/11268/16958
dc.language.isoeng
dc.peerreviewedSi
dc.relation.publisherversionhttps://doi.org/10.1016/j.tice.2026.103436
dc.rightsAttribution 4.0 International
dc.rights.accessRightsopen access
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subject.otherBiociencias
dc.subject.otherHipocampo
dc.subject.otherInmunohistoquímica
dc.subject.otherMicroscopía electrónica
dc.subject.sdgGoal 3: Ensure healthy lives and promote well-being for all at all ages
dc.subject.unescoEnfermedad del sistema nervioso
dc.subject.unescoMedicina preventiva
dc.subject.unescoInvestigación médica
dc.titleAmyloid-β and tau pathology induce a reduction of the G-protein Gαo subunit in the mouse hippocampus
dc.typejournal article
dc.type.hasVersionVoR
dspace.entity.typePublication

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