A Sustained-Release Thermoplastic Polyurethane/Poly L-Lactide-Co-DL-Lactide (TPU/PLDLA) Cyclosporine-A Implant for the Treatment of Canine Keratoconjunctivitis Sicca: A Retrospective Case Series

Abstract

To evaluate the efficacy of a Thermoplastic Polyurethane/Poly L- Lactide- Co- DL- Lactide (TPU/PLDLA) polymer blend containing cyclosporine (CsA) for the treatment of keratoconjunctivitis sicca (KCS) in dogs. The TPU/PLDLA- CsA implant shows potential as an alternative to conventional topical CsA treatment for canine KCS, providing sustained release and reducing the need for frequent drug applications. The implant was generally well- tolerated, with observed improvements in tear production and inflammation reduction. Sedation was used for implantation, making the procedure less invasive compared to the general anesthesia required for some other implants. However, further studies with larger sample sizes and extended follow- up are required to confirm its long- term efficacy and safety, as well as to refine dosing and implantation protocols for optimal therapeutic outcomes.