Beyond maternal exercise: paternal exercise adaptations mediated by sperm microRNA signatures

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Preclinical and clinical evidence shows that maternal exercise can contribute to the cardiometabolic health of offspring. Recent tantalizing findings also point to several paternal factors, notably sperm microRNAs, that can mediate the intergenerational transmission of exercise benefits.

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Plaza-Florido, A., Pérez-Prieto, I., Galvão, D. A., & Lucia, A. (2026). Beyond maternal exercise: Paternal exercise adaptations mediated by sperm microRNA signatures. Nature Reviews Urology. https://doi.org/10.1038/s41585-026-01138-7

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