Tamoxifen metabolism in breast cancer treatment: Taking the focus off the CYP2D6 gene

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dc.contributor.authorNovillo Villajos, Apolonia
dc.contributor.authorRomero Lorca, Alicia
dc.contributor.authorGaibar Alonso, María
dc.contributor.authorRubio Alonso, Margarita
dc.contributor.authorFernández Santander, Ana
dc.date.accessioned2016-10-13T10:11:37Z
dc.date.available2016-10-13T10:11:37Z
dc.date.issued2017
dc.description.abstractTamoxifen (TAM) has been widely used to treat estrogen receptor (ER)-positive breast cancer, and has led to reduction of 50% in the annual recurrence rate and 30% in breast cancer mortality after 5 years of treatment.1 The prodrug TAM is a selective ER modulator that antagonizes ERs in cancer cells. However, compared with its two active metabolites 4-hydroxy-TAM (4-OH-TAM) and endoxifen, it is a relatively weak antiestrogen.spa
dc.description.filiationUEMspa
dc.description.impact3.812 JCR (2017) Q1, 50/261 Pharmacology and Pharmacy; Q2, 49/171 Genetics and Heredityspa
dc.description.sponsorshipSin financiaciónspa
dc.identifier.citationNovillo, A., Romero-Lorca, A., Gaibar, M., Rubio, M., & Fernández-Santander, A. (2017). Tamoxifen metabolism in breast cancer treatment: Taking the focus off the CYP2D6 gene. The Pharmacogenomics Journal, 17(2), 109-111. DOI: 10.1038/tpj.2016.73spa
dc.identifier.doi10.1038/tpj.2016.73
dc.identifier.issn1470269X
dc.identifier.issn14731150
dc.identifier.urihttp://hdl.handle.net/11268/5867
dc.language.isoengspa
dc.peerreviewedSispa
dc.rights.accessRightsrestricted accessspa
dc.subject.uemTamoxifenospa
dc.subject.uemMamas - Cáncerspa
dc.subject.unescoCáncerspa
dc.titleTamoxifen metabolism in breast cancer treatment: Taking the focus off the CYP2D6 genespa
dc.typejournal articlespa
dspace.entity.typePublication
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relation.isAuthorOfPublication.latestForDiscovery4b02f8da-816e-471d-b72b-000a5a37e0da

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