Clear Cell Renal Cell Carcinoma: A Test Bench for Investigating Tumor Complexity

Abstract

Clear cell renal cell carcinoma (CCRCC), by far the most common renal cancer subtype, is an aggressive tumor variant, serving in recent years as a prolific test bench in cancer research. Many of the recent advances in our knowledge about intratumor heterogeneity, tumor evolution, eco-oncology, metastatic competence, and therapeutic resistance have been achieved by analyzing this neoplasm [1–3]. The varied spectrum of papers collected in this Special Issue, composed of five articles, six reviews, one systematic review, and one commentary, confirms this fact.