Comparative activities of TR-700 (torezolid) against staphylococcal blood isolates collected in Spain
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Betriu, Carmen
Morales Kucharski, María Gracia
Rodríguez-Avial, Icíar
Culebras, Esther
Gómez, María
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Abstract
The in vitro activity of TR-700 (torezolid) was evaluated against a collection of 660 staphylococcal blood isolates. TR-700 showed excellent activity against all the staphylococci tested. The MIC(50) and MIC(90) values of TR-700, linezolid, daptomycin, and vancomycin against methicillin-resistant Staphylococcus aureus (MRSA) isolates were 0.25 and 0.5, 2 and 4, 0.5 and 0.5, and 1 and 2 microg/ml, respectively. TR-700 demonstrated greater in vitro potency than linezolid against staphylococci, including linezolid-resistant and vancomycin-nonsusceptible strains, and was 32-fold more active than linezolid against the seven cfr-positive MRSA strains tested.
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Betriu, C., Morales, G., Rodríguez-Avial, I., Culebras, E., Gómez, M., López-Fabal, F., & Picazo, J. J. (2010). Comparative activities of TR-700 (torezolid) against staphylococcal blood isolates collected in Spain. Antimicrobial Agents and Chemotherapy, 54(5), 2212-2215.