Serum chloride and the response to hydrochlorothiazide in patients with acute heart failure: a post-hoc analysis from the CLOROTIC trial
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García Escrivá, David
Pérez Silvestre, José
Núñez, Julio
Casado, Jesús
Morales Rull, José Luis
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SDG
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Abstract
Hypochloremia is associated with worse prognosis and diuretic resistance in acute heart failure (AHF). This study investigated whether serum chloride is associated with the efficacy and safety of hydrochlorothiazide in patients with AHF.
In patients with AHF, the addition of hydrochlorothiazide to loop diuretics enhances decongestion regardless of the baseline serum chloride.
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García-Escrivá, D., Pérez-Silvestre, J., Núñez, J., Casado, J., Luís Morales-Rull, J., Sánchez-Marteles, M., Conde-Martel, A., Llàcer, P., Salamanca-Bautista, P., Plasín, M. Á., Manuel Cerqueiro, J., Gil, P., Manzano, L., Formiga, F., & Trullàs, J. C. (2026). Serum chloride and the response to hydrochlorothiazide in patients with acute heart failure: A post-hoc analysis from the CLOROTIC trial. Revista Española de Cardiología (English Edition), S1885585726001040. https://doi.org/10.1016/j.rec.2026.04.006