Díaz Rivas, J. O.Herrera Carrera, E.Gallegos Infante, José AlbertoRocha Guzmán, Nuria E.González Laredo, Rubén F.Moreno Jiménez, Martha R.Ramos Gómez, M.Reynoso Camacho, R.Larrosa Pérez, MarGallegos Corona, M. A.2015-05-192015-05-192015Díaz-Rivas, J. O., Herrera-Carrera, E., Gallegos-Infante, J. A., Rocha-Guzmán, N. E., González-Laredo, R. F., Moreno-Jiménez, M. R., Larrosa-Pérez, M., & Gallegos-Corona, M. A. (2015). Gastroprotective potential of Buddleja scordioides Kunth Scrophulariaceae infusions; Effects into the modulation of antioxidant enzymes and inflammation markers in an in vivo model. Journal of ethnopharmacology, 169, 280-286.03788741http://hdl.handle.net/11268/3949Ethnopharmacological relevance: A common plant used to treat several gastric disorders is Buddleja scordioides Kunth,commonly known as salvilla. Aim of thes tudy: To detect inflammatory markers,in order to evaluate the gastroprotective potential of salvilla infusions,as this could have beneficial impact on the population exposed to gastric ulcers and colitis. Materials and methods: The present work attempted infusions were prepared with B. scordioides (1% w/w) lyophilized and stored.Total phenolic content and GC–MS analysis were performed. Wistar rats were divided into five groups a negative vehicle control,an indomethacin group,and three experimental groups,named preventive,curative,and suppressive. All rats were sacrificed under deep ether anesthesia(6h)after the last oral administration of indomethacin/infusion.The rat stomachs were promptly excised,weighed,and chilled in ice-cold and 0.9%NaCl.Histological analysis,nitrites quantification and immunodetection assays were done. Results: B.scordioides infusions markedly reduced the visible hemorrhagic lesions induced byindomethacin in rat stomachs,also showed down-regulation of COX2, IL-8 and TNFα and up-regulation of COX-1with a moderate down-regulation of NFkB and lower amount of nitrites.However,this behavior was dependent on the treatment,showing most down-regulation of COX-2,TNFα and IL-8 in the curative treatment;more down-regulation of NF-kB in the preventive treatment;and more up-regulation of COX-1 for the suppressor and preventive treatments. Conclusion: The anti-inflammatory potential of B. scordioides infusions could be related with the presence of polyphenols as quercetin in the infusion and how this one is consumed.engBuddleja scordioidesjournal article10.1016/j.jep.2015.04.024.restricted accessMedicinas alternativasPlantasPlanta medicinal