Llavero Bernal, FranciscoArrazola Sastre, AlazneLuque Montoro, MiriamMartín Casanueva, Miguel ÁngelArenas, JoaquínLucía Mulas, AlejandroZugaza, José Luis2020-04-022020-04-022021Llavero, F., Arrazola Sastre, A., Luque Montoro, M., Martín Casanueva, M. Á., Arenas, J., Lucía Mulas, A., & Zugaza, J. L. (2019). Small GTPases of the Ras superfamily and glycogen phosphorylase regulation in T cells. Small GTPases, 12(2), 106-113. https://doi.org/10.1080/21541248.2019.16659682154-12562154-1248http://hdl.handle.net/11268/8895Small GTPases, together with their regulatory and effector molecules, are key intermediaries in the complex signalling pathways that control almost all cellular processes, working as molecular switches to transduce extracellular cues into cellular responses that drive vital functions, such as intracellular transport, biomolecule synthesis, gene activation and cell survival. How all of these networks are linked to metabolic pathways is a subject of intensive study. Because any response to cellular action requires some form of energy input, elucidating how cells coordinate the signals that lead to a tangible response involving metabolism is central to understand cellular activities. In this review, we summarize recent advances in our understanding of the molecular basis of the crosstalk between small GTPases of the Ras superfamily, specifically Rac1 and Ras/Rap1, and glycogen phosphorylase in T lymphocytes.engjournal article10.1080/21541248.2019.1665968restricted accessBiología molecularBiología molecular