Pérez Leal, MartínEl Helou, BouchraRoger Laparra, Inés2025-03-152025-03-05Pérez‐Leal, M., El Helou, B., & Roger, I. (2025). Electronic cigarettes versus combustible cigarettes in oral squamous cell cancer patients: A systematic review. Journal of Oral Pathology & Medicine, jop.13618. Advance online publication. https://doi.org/10.1111/jop.136180904-25121600-0714http://hdl.handle.net/11268/14267Introduction: Oral squamous cell carcinoma (OSCC) is associated with tobacco. In order to reduce the burden of smoking, e-cigarettes emerge as devices to aid cessation of tobacco addiction. However, growing evidence shows that e-cigarettes can leadto harmful effects.Objetives: The aim is to analyze the prevalence of combustible or electronic cigarette smoking in patients with a diagnosis ofOSCC, analyze the prevalence of precancerous lesions in smokers of combustible or electronic cigarettes, and describe the loca-tion and differentiation of OSCC.Methodology: PRISMA guidelines were followed. PubMed, Web of Science, and Scopus were used, introducing specific algo-rithms related to electronic and combustible cigarettes associated with OSCC.Results: Of 400 potentially eligible articles, 15 met the inclusion criteria: 13 studies on combustible and 2 on e-cigarettes.Regarding combustible, the mean smoking prevalence in patients was 56.38% with a prevalence of precancerous lesions of 2.50%,among other parameters. For the e-cigarette group, the mean prevalence was 4.26% with a prevalence of precancerous lesions of2.20%. Tongue and lower lip are common and frequent locations in both cigarettes.Conclusions: Despite certain limitations, developing OSCC is mostly associated with combustible cigarettes and to a lesserextent with e-cigarettes. Both cigarettes show a similar prevalence of precancerous lesions, with the tongue as a common andfrequent locationengjournal article10.1111/jop.13618restricted accessCáncerTabacoGoal 3: Ensure healthy lives and promote well-being for all at all ages