Guerra Minuzz, LucieleBatatinha, HelenaWeyh, ChristopherLakshmi, Vidya Srokshna BalasubramanianFiuza Luces, María del CarmenGonzález Gálvez, BeatrizLucía Mulas, AlejandroTeixeira, Ana MariaSommer, NataschaRosa Neto, José Cesaret al.2026-07-242026-07-242025Minuzzi, L. G., Batatinha, H., Weyh, C., Balasubramanian Lakshmi, V. S., Fiuza-Luces, C., Gálvez, B. G., Lucia, A., Teixeira, A. M., Sommer, N., Rosa-Neto, J. C., Lira, F. S., & Krüger, K. (2025). Natural killer cells from endurance-trained older adults show improved functional and metabolic responses to adrenergic blockade and mTOR inhibition. Scientific Reports, 15(1), 25380. https://doi.org/10.1038/s41598-025-06057-y2045-2322https://hdl.handle.net/11268/17318Aging is associated with immune dysfunction, but long-term endurance training may confer protective effects on immune cell function. This study investigates how natural killer (NK) cell phenotypes, functional markers, and metabolism differ between endurance-trained and untrained older adults. Mitochondrial analysis revealed that trained NK cells exhibited higher basal and maximal OCR, greater spare respiratory capacity, and OCR/ECAR ratio, reflecting superior metabolic fitness. These findings indicate that endurance-trained older adults have NK cells with greater functional adaptability, reduced senescence, and enhanced metabolism under inflammatory and pharmacological stress.engAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/Ciencias del DeporteCélulas Asesinas NaturalesEnvejecimientoInmunosenescenciajournal article10.1038/S41598-025-06057-Yopen accessCiencias médicasInmunologíaGerontologíaGoal 3: Ensure healthy lives and promote well-being for all at all agesGoal 10: Reduce inequality within and among countries