Terreros Roncal, JuliaMoreno Jiménez, Elena P.Flor García, MiguelRodríguez Moreno, Carla B.Trinchero, M. F.Cafini Barrado, FabioRábano, AlbertoLlorens Martín, María2023-08-042023-08-042021Terreros-Roncal, J., Moreno-Jiménez, E. P., Flor-García, M., Rodríguez-Moreno, C. B., Trinchero, M. F., Cafini, F., Rábano, A., & Llorens-Martín, M. (2021). Impact of neurodegenerative diseases on human adult hippocampal neurogenesis. Science, 374(6571), 1106–1113. https://doi.org/10.1126/science.abl51630036-80751095-9203http://hdl.handle.net/11268/12253Disrupted hippocampal performance underlies psychiatric comorbidities and cognitive impairments in patients with neurodegenerative disorders. To understand the contribution of adult hippocampal neurogenesis (AHN) to amyotrophic lateral sclerosis, Huntington’s disease, Parkinson’s disease, dementia with Lewy bodies, and frontotemporal dementia, we studied postmortem human samples. We found that adult-born dentate granule cells showed abnormal morphological development and changes in the expression of differentiation markers. The ratio of quiescent to proliferating hippocampal neural stem cells shifted, and the homeostasis of the neurogenic niche was altered. Aging and neurodegenerative diseases reduced the phagocytic capacity of microglia, triggered astrogliosis, and altered the microvasculature of the dentate gyrus. Thus, enhanced vulnerability of AHN to neurodegeneration might underlie hippocampal dysfunction during physiological and pathological aging in humans.engTrastornos del Neurodesarrollojournal article10.1126/science.abl5163open accessNeurologíaCerebroEnfermedad del sistema nervioso