Clemente Suárez, Vicente JavierMielgo Ayuso, JuanQuiles Morales, José LuísVarela López, AlfonsoAranda Ramírez, Pilar2018-11-272018-11-272017Clemente-Suárez, V. J., Mielgo-Ayuso, J., Quiles, J. L., Varela-Lopez, A., & Aranda, P. (2017). Effect of α-tocopherol megadoses on hematologic parameters and antioxidant capacity of rats in an ultraendurance probe. Physiology international, 104(4), 291-300. https://dx.doi.org/10.1556/2060.104.2017.4.22498-602Xhttp://hdl.handle.net/11268/7628This study was aimed to analyze the effect of two different megadoses of α-tocopherol (vit E) in the antioxidant activity and red and white blood series of Wistar rats after a 180-min ultraendurance probe. Three groups of 10 rats were analyzed; VEAG: acute administration of a megadoses of 5,000 IU/kg of vit E the day before the probe; VECG: chronic administration of 1,000 IU/kg/day of vit E for 6 days before the probe; CG: placebo administration. VEAG presented white cells, red blood cells, hematocrit, hemoglobin values significantly higher than CG and VECG (p < 0.05). The mean corpuscular hemoglobin and lymphocytes concentrations were significantly higher in the VECG than in the other two groups (p < 0.05). Similarly, VEAG presented a significantly higher vit E blood concentration than VECG and CG (p < 0.05), and VECG than CG (p < 0.05). Finally, we found a significantly positive correlation between trolox equivalent antioxidant capacity (TEAC) and red blood cells concentration (r = 0.374) and a significantly inverse correlation between TEAC and blood lactate concentration (r = −0.365). Our findings suggest that acute vit E megadoses could protect against transitory sport anemia symptoms and increase the white blood cell count in comparison with the chronic dose and control groups after an ultraendurance probe.engjournal article10.1556/2060.104.2017.4.2restricted accessAntioxidantesHematologíaVitamina EVitaminaInvestigaciónDesarrollo fisiológico