Hampel, HaraldNisticò, RobertSeyfried, Nicholas T.Levey, Allan I.Modeste, EricaLemercier, PabloBaldacci, FilippoToschi, NicolaLucía Mulas, AlejandroLista, SimoneEt al.2021-06-012021-06-012021Hampel, H., Nisticò, R., Seyfried, N. T., Levey, A. I., Modeste, E., Lemercier, P., Baldacci, F., Toschi, N., Garaci, F., Perry, G., Emanuele, E., Valenzuela, P. L., Lucía, A., Urbani, A., Sancesario, G. M., Mapstone, M., Corbo, M., Vergallo, A., Lista, S., & Alzheimer Precision Medicine Initiative (APMI) (2021). Omics sciences for systems biology in Alzheimer's disease: State-of-the-art of the evidence. Ageing Research Reviews, 69, 101346. https://doi.org/10.1016/j.arr.2021.1013461568-16371872-9649http://hdl.handle.net/11268/10080Alzheimer's disease (AD) is characterized by non-linear, genetic-driven pathophysiological dynamics with high heterogeneity in biological alterations and disease spatial-temporal progression. Human in-vivo and post-mortem studies point out a failure of multi-level biological networks underlying AD pathophysiology, including proteostasis (amyloid-β and tau), synaptic homeostasis, inflammatory and immune responses, lipid and energy metabolism, oxidative stress. Therefore, a holistic, systems-level approach is needed to fully capture AD multi-faceted pathophysiology. Omics sciences - genomics, epigenomics, transcriptomics, proteomics, metabolomics, lipidomics - embedded in the systems biology (SB) theoretical and computational framework can generate explainable readouts describing the entire biological continuum of a disease. Such path in Neurology is encouraged by the promising results of omics sciences and SB approaches in Oncology, where stage-driven pathway-based therapies have been developed in line with the precision medicine paradigm. Multi-omics data integrated in SB network approaches will help detect and chart AD upstream pathomechanistic alterations and downstream molecular effects occurring in preclinical stages. Finally, integrating omics and neuroimaging data - i.e., neuroimaging-omics - will identify multi-dimensional biological signatures essential to track the clinical-biological trajectories, at the subpopulation or even individual level.engEnfermedad de alzheimerBiomarcadoresBiología de sistemasjournal article10.1016/j.arr.2021.101346restricted accessFisiología humanaBiología molecular