Pesqué, DavidPlanella Fontanillas, NidiaBorrego, LeopoldoSanz Sánchez, TatianaZaragoza Ninet, VioletaSerra Baldrich, EstherSilvestre Salvador, Juan FranciscoCórdoba Guijarro, SusanaSánchez Gilo, AraceliGiménez Arnau, Ana MaríaEt al.2025-01-142025-01-142025Pesqué, D., Planella‐Fontanillas, N., Borrego, L., Sanz‐Sánchez, T., Zaragoza‐Ninet, V., Serra‐Baldrich, E., Miquel‐Miquel, F. J., Silvestre‐Salvador, J. F., Córdoba‐Guijarro, S., Sánchez‐Gilo, A., Mercader‐García, P., Navarro‐Triviño, F. J., Ortiz‐de‐Frutos, F. J., Tous‐Romero, F., Rodríguez‐Serna, M., Melé‐Ninot, G., Barrabés‐Torrella, C., Ruiz‐González, I., Pastor‐Nieto, M. A., … Giménez‐Arnau, A. M. (2025). Patch test results to the Spanish baseline patch test series according to age groups: A multicentric prospective study from 2019 to 2023. Contact Dermatitis, 92(2), 120-130. https://doi.org/10.1111/cod.147020105-18731600-0536http://hdl.handle.net/11268/13470Introduction: Patch test results may be influenced by age-related factors. However, there is still discordant evidence between age and patch test results. Objectives: We aim to evaluate the patch test results reflecting skin sensitisation, their relevance and association with clinical features by age group. Methods: Prospective multicentric study of all patients patch tested with the Spanish baseline series in participating centres. Age groups were pre-defined as children (0- to 11-years), adolescents (12- to 18-years), young adults (19- to 30-years), middleaged adults (31- to 65-years) and older adults (≥66-years). Occurrence of sensitisation, relevance and clinical features were compared by age group. Factors associated with skin sensitisation were investigated with multivariate logistic regression. Results: A total of 13 368 patients were patch-tested. Differences in positive patch test results and relevance by age were detected with the highest proportion in middle-aged adults. Age-related trend differences were found for nickel, potassium dichromate, caines, colophony, Myroxylon pereirae resin, 2-hydroxyethyl methacrylate and limonene hydroperoxide. The multivariate logistic analysis (adjusted for sex, atopic dermatitis, body location and occupational dermatitis) showed an association between the age group of 31–65 (OR: 1.41, 95% CI: 1.26–1.58) and above 66-years (OR: 1.15, 95% CI: 1.01–1.32) with a higher proportion of positive results, compared with young adults. Conclusions: Positive patch test results vary according to age, with the highest occurrence in middle-aged adults. Most haptens did not present age-related differences, reinforcing the use of baseline series regardless of age.engAttribution-NonCommercial 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc/4.0/DermatologíaPruebas del Parchejournal article10.1111/cod.14702open accessTratamiento médicoEnfermedad de la pielGoal 3: Ensure healthy lives and promote well-being for all at all agesGoal 4: Quality educationGoal 9: Build resilient infrastructure, promote sustainable industrialization and foster innovation