Navarro Jiménez, EduardoBenítez Agudelo, Juan CamiloBeltrán Velasco, Ana IsabelRamos Campo, Domingo JesúsVillanueva- Tobaldo, Carlota ValeriaMartín Rodríguez, AlexandraClemente Suárez, Vicente JavierBelinchón de Miguel, PedroTornero Aguilera, José Francisco2025-09-272025-09-272025Clemente-Suarez, V. J., Navarro-Jiménez, E., Benitez-Agudelo, J. C., Beltrán-Velasco, A. I., Belinchón-deMiguel, P., Ramos-Campo, D. J., Villanueva-Tobaldo, C. V., Martín-Rodríguez, A., & Tornero-Aguilera, J. F. (2025). The multifaceted impact of circadian disruption on cancer risk: A systematic review of insights and economic implications. Journal of the National Cancer Center, S2667005425000651. https://doi.org/10.1016/j.jncc.2025.04.0052667-0054https://hdl.handle.net/11268/16238Circadian disruption has emerged as a significant risk factor for cancer, driven by mechanisms such as hormonal imbalances, impaired DNA repair, immune suppression, and metabolic dysregulation. Modern societal patterns—shift work, artificial light at night, and irregular sleep schedules—have exacerbated these risks. This study conducts a systematic review following Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) guidelines, screening over 500 studies published between 2003 and 2023.engAttribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/journal article10.1016/j.jncc.2025.04.005open accessCáncerMedicina preventivaBiología molecularGoal 3: Ensure healthy lives and promote well-being for all at all agesGoal 4: Quality education