Verde Rello, ZoraidaGonzalez-Moro, Jose MiguelChicharro García, Luis MiguelReinoso Barbero, LuisBandrés Moya, FernandoGómez Gallego, FélixSantiago Dorrego, Catalina2016-10-302016-10-302017Verde, Z., González-Moro, J. M. R., Chicharro, L. M., Reinoso-Barbero, L., Bandrés, F., Gómez-Gallego, F., & Santiago, C. (2017). A Paradox: α-Klotho Levels and Smoking Intensity. Lung, 195(1), 53-57. DOI: 10.1007/s00408-016-9944-60341-2040http://hdl.handle.net/11268/5937Reports regarding smoking differences in aklotho expression have provided conflicting results. In the current study we focused on the influence of smoking intensity to serum levels of the aging molecule a-klotho in healthy smokers. 40 middle aged healthy smokers without airway obstruction or restriction were selected for the analysis. Serum levels of soluble a-klotho were significantly higher in heavy smokers (P\0.001). These results are in agreement with the possibility that a-klotho acts as anti-inflammatory molecule and strengthen the hypothesis that an increase of serum levels of a-klotho might be a compensatory response to smoking stress in healthy population.engjournal article10.1007/s00408-016-9944-6restricted accessMédicinaCiencias médicas