Lucas Moreno, Beatriz deMartín Pérez, LauraBernal, AuroraGonzález Gálvez, Beatriz2021-03-042021-03-042020de Lucas, B., Pérez, L. M., Bernal, A., & Gálvez, B. G. (2020). Ultrasound Therapy: Experiences and Perspectives for Regenerative Medicine. Genes, 11(9), 1086. https://doi.org/10.3390/genes110910862073-4425http://hdl.handle.net/11268/9888Ultrasound has emerged as a novel tool for clinical applications, particularly in the context of regenerative medicine. Due to its unique physico-mechanical properties, low-intensity ultrasound (LIUS) has been approved for accelerated fracture healing and for the treatment of established non-union, but its utility has extended beyond tissue engineering to other fields, including cell regeneration. Cells and tissues respond to acoustic ultrasound by switching on genetic repair circuits, triggering a cascade of molecular signals that promote cell proliferation, adhesion, migration, differentiation, and extracellular matrix production. LIUS also induces angiogenesis and tissue regeneration and has anti-inflammatory and anti-degenerative effects. Accordingly, the potential application of ultrasound for tissue repair/regeneration has been tested in several studies as a stand-alone treatment and, more recently, as an adjunct to cell-based therapies. For example, ultrasound has been proposed to improve stem cell homing to target tissues due to its ability to create a transitional and local gradient of cytokines and chemokines. In this review, we provide an overview of the many applications of ultrasound in clinical medicine, with a focus on its value as an adjunct to cell-based interventions. Finally, we discuss the various preclinical and clinical studies that have investigated the potential of ultrasound for regenerative medicine.engAttribution-NonCommercial-NoDerivatives 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-nd/4.0/Células madreTerapia por ultrasonidoMedicina regenerativajournal article10.3390/genes11091086open accessCélulaTecnología médica