Steiner, MartinaEsteban Ortega, María del MarThuissard Vasallo, Israel JohnGarcía Lozano, IsabelGarcía González, Alejandro JavierPérez Blázquez, EugenioSambricio, JavierGarcía Aparicio, Ángel M.Casco Silva, Bruno FranciscoMuñoz Fernández, SantiagoEt al.2024-06-162024-06-162024Steiner, M., Del Mar Esteban-Ortega, M., Thuissard-Vasallo, I., García-Lozano, I., García-González, A. J., Pérez-Blázquez, E., Sambricio, J., García-Aparicio, Á., Casco-Silva, B. F., Sanz-Sanz, J., Valdés-Sanz, N., Fernández-Espartero, C., Díaz-Valle, T., Gurrea-Almela, M., Fernández-Melón, J., Gómez-Resa, M., Pato-Cour, E., Díaz-Valle, D., Méndez-Fernández, R., Navío, T., … ChOroidal Thickness in ESpondylitis (COnTEST) Study Group (2024). Choroidal Thickness Is a Biomarker Associated With Response to Treatment in Ankylosing Spondylitis. Journal of Clinical Rheumatology : Practical Reports on Rheumatic & Musculoskeletal Diseases, 30(4), 131–137. https://doi.org/10.1097/RHU.00000000000014581076-16081536-7355http://hdl.handle.net/11268/12927Objective Choroidal thickness (CT) has been evaluated as a marker of systemic inflammation in ankylosing spondylitis (AS). This study evaluates the CT of AS patients before and after 6 months of biological treatment. Methods This longitudinal multicenter study evaluated CT in 44 AS patients. The correlations between CT and C-reactive protein (CRP) with disease activity indices were calculated. The concordance between CT and CRP was determined. We assessed factors associated with response to treatment. Clinically important improvement was defined as a decrease in Ankylosing Spondylitis Disease Activity Score of 1.1 points or greater. Results Forty-four eyes in patients aged 18 to 65 years were included. Mean CT values were significantly higher at baseline than after 6 months of treatment (baseline: 355.28 ± 80.46 μm; 6 months: 341.26 ± 81.06 μm; p < 0.001). There was a 95% concordance between CT and CRP at baseline and 6 months. Clinically important improvement was associated with lower baseline CT and age as independent factors (odds ratios, 0.97 [95% confidence interval, 0.91–0.93; p = 0.009] and 0.81 [95% confidence interval, 0.7–0.95; p = 0.005]), with baseline CT of less than 374 μm (sensitivity 78%, specificity 78%, area under the curve 0.70, likelihood ratio 3.6). Conclusions Choroidal thickness decreased significantly after 6 months of biological treatment in all treatment groups. Choroidal thickness and CRP had a 95% concordance. A high CT was associated with a risk of biological treatment failure. Choroidal thickness can be considered a useful biomarker of inflammation and a factor associated with response to treatment in AS.engReumatologíaEspondilitisjournal article10.1097/RHU.0000000000001458open accessCiencias médicasGoal 3: Ensure healthy lives and promote well-being for all at all ages