Ramírez Jiménez, MiguelFernández Elías, Valentín EmilioMorales Palomo, FélixOrtega Fonseca, Juan FernandoMora Rodríguez, Ricardo2018-11-062018-11-062018Ramirez-Jimenez, M., Fernandez-Elias, V., Morales-Palomo, F., Ortega, J. F., & Mora-Rodriguez, R. (2018). Intense aerobic exercise lowers blood pressure in individuals with metabolic syndrome taking antihypertensive medicine. Blood Pressure Monitoring, 23(5), 230-236. https://doi.org/10.1097/MBP.0000000000000328359-5237http://hdl.handle.net/11268/7542OBJECTIVE: There is a growing tendency for physicians to prescribe exercise in accordance with the 'exercise is medicine' global health initiative. However, the exercise-pharmacologic interactions for controlling blood pressure are not well described. Our purpose was to study whether angiotensin II receptor type 1 blocker (ARB) antihypertensive medicine enhances the blood pressure-lowering effects of intense exercise. PARTICIPANTS AND METHODS: Fifteen hypertensive individuals with metabolic syndrome chronically medicated with ARB underwent two exercise trials in a blind randomized order. One trial was conducted after taking their habitual dose of ARB (ARB MED trial) and another after 48 h of placebo medicine (i.e. dextrose; PLAC trial). RESULTS: After placebo medication, brachial systolic blood pressure increased by 5.5 mmHg [P=0.009; effect size (ES)=0.476] and diastolic by 2.5 mmHg (P=0.030; ES=0.373). Exercise reduced systolic and diastolic blood pressures to the same extent in ARB MED and PLAC trials (7 and 8 mmHg, respectively, for systolic and 5 and 4 mmHg, respectively, for diastolic, all P<0.05). Pulsatile measures of arterial stiffness did not reveal an interaction effect between exercise and medication. However, postocclusion reactive hyperemia increased after exercise only in the ARB MED trial (361±169 to 449±240% from baseline; P=0.033; ES=0.429). CONCLUSION: ARBs and a bout of intense exercise each have an independent effect on lowering blood pressure in hypertensive individuals, and these effects are additive.engjournal article10.1097/MBP.0000000000000328restricted accessPresión sanguíneaEjercicio físicoSistema cardiovascularDeporte