Ugarte, Giorgia D.Díaz, EmilioBiscaia Fernández, José MiguelStehberg, JimmyMontecino, MartínVan Zundert, Brigitte2013-11-272013-11-272013Ugarte, G. D., Díaz, E., Biscaia-Fernández, J. M., Stehberg, J., Montecino, M., & Zundert, B. (2013). Transcription of the pain‐related TRPV1 gene requires Runx1 and C/EBPβ factors. Journal of Cellular Physiology, 228(4), 860-870.00219541http://hdl.handle.net/11268/1004Transient Receptor Potential Vanilloid type 1 channel (TRPV1) is an important endogenous transducer of noxious heat and chemical stimuli and is required during development of inflammatory hypersensitivity. The transcription factor Runx1 is known to play a relevant role in sensory neuron differentiation as it controls the expression of several sensory nociceptive receptors, including TRPV1. Here, we show that Runx1 up-regulates TRPV1 transcription activity by interacting directly with the proximal TRPV1 gene promoter sequence. Importantly, C/EBPβ a well-established heterodimer partner of Runx1 also binds to the TRPV1 promoter and cooperates with Runx1 to further stimulate TRPV1 transcription. Our results support a mechanism where Runx1-C/EBPβ-containing transcription regulatory complexes are recruited to the TRPV1 gene promoter to modulate TRPV1 expression in dorsal root ganglia neurons.engjournal article10.1002/jcp.24236restricted accessGenética humanaNeurología