Priego, TeresaIbáñez de Cáceres, InmaculadaMartín, Ana IsabelVillanúa, María de los ÁngelesLópez-Calderón, Asunción2016-08-252016-08-252003Priego, T., Ibáñez de Cáceres, I., Martín, A. I., Villanúa, M. A., & López-Calderón, A. (2003). Endotoxin decreases serum IGFBP-3 and liver IGFBP-3 mRNA: Comparison between Lewis and Wistar rats. Molecular and Cellular Endocrinology, 199(1-2), 23-28.03037207http://hdl.handle.net/11268/5679We studied the IGFBP-3 response to endotoxin, in Wistar and Lewis rats. Compared to Wistar rats, Lewis rats have a reduced adrenal and IGF-I response to inflammatory stimuli. Rats received two injections of 1 mg/kg of lipopolysaccharide (LPS) and were killed 4 h after the second injection. LPS decreased serum concentrations of GH in Wistar (P<0.05), but not in Lewis rats. However, serum IGFBP-3 was decreased both in Wistar and in Lewis rats. Furthermore, LPS administration decreased IGFBP-3 gene expression in the liver in both rat strains (P<0.01). Lewis rats had lower serum IGFBP-3 than Wistar rats (P<0.01). This difference could be secondary to the increased IGFBP-3 proteolysis in serum observed in Lewis rats. These data indicate that acute inflammation inhibits serum concentrations of IGFBP-3 by decreasing its synthesis in the liver, rather than increasing its proteolysis. This effect seems to be GH and IGF-I independent.engjournal article10.1016/S0303-7207(02)00356-8restricted accessEndocrinologíaMetabolismoBiología humanaSistema endocrinoBiología celular