Domínguez Rodríguez, SaraTagarro García, AlfredoPalma, PaoloFoster, CarolinePuthanakit, ThanyaweeJupimai, ThidaratCotugno, NicolaAnanworanich, JintanatZangari, PaolaNastuoli, EleniEt al.2021-12-022021-12-022019Domínguez-Rodríguez, S., Tagarro, A., Palma, P., Foster, C., Puthanakit, T., Jupimai, T., Cotugno, N., Ananworanich, J., Zangari, P., Nastouli, E., Muñoz-Fernández, M. Á., Navarro, M. L., Giaquinto, C., Rossi, P., Kuhn, L., & Rojo, P. (2019). Reduced Time to Suppression among Neonates with HIV Initiating Antiretroviral Therapy Within 7 Days after Birth. Journal of Acquired Immune Deficiency Syndromes, 82(5), 483-490. https://doi.org/10.1097/QAI.00000000000021881525-41351944-7884http://hdl.handle.net/11268/10534There are limited data on infants with HIV starting antiretroviral therapy (ART) in the neonatal period. We investigated the association between the timing of ART initiation and time-to-suppression among infants who tested HIV-positive and initiated ART within the first 28 days of life. The effect was estimated using cumulative probability flexible parametric spline models and a multivariable generalized additive mixed model was performed to test non-linear associations. Forty-four neonates were included. Nineteen (43.2%) initiated ART within 7 days of life and 25 (56.8%) from 8 to 28 days. Infants treated within 7 days were 4-fold more likely to suppress earlier than those treated after 7 days (HR 4.01 [1.7;9.5]). For each week the ART initiation was delayed, the probability of suppression decreased by 35% (HR 0.65 [0.46;0.92]). Age at ART start was linearly associated with time-to-suppression. However, a linear association with normally distributed residuals was not found between baseline VL and time-to-suppression, with no association found when baseline viral loads were ≤ 5 log(10) copies/ml, but with exponential increase in time-to-suppression with > 5 log(10) copies/ml at baseline. Starting ART within 7 days of life led to 4-fold faster time to viral suppression, in comparison to initiation in 8 to 28 days.engAntirretroviralesRecién nacidojournal article10.1097/QAI.0000000000002188restricted accessInvestigación médicaSidaPediatría