Mínguez Esteban, IsabelCueva Reguera, Mónica de laAlmazán Polo, JaimeAbuín Porras, VanesaRomero Morales, CarlosBravo Aguilar, María2025-11-232025-11-232025Mínguez-Esteban, I., De La Cueva-Reguera, M., Abuín-Porras, V., Romero-Morales, C., Almazán-Polo, J., & Bravo-Aguilar, M. (2025). Acute sonographic changes in common carotid artery after NESA neuromodulation intervention in healthy adults: A randomized controlled clinical trial. Frontiers in Neuroscience, 19, 1526236. https://doi.org/10.3389/fnins.2025.15262361662-453Xhttps://hdl.handle.net/11268/16509Introduction: The endothelium plays a key role in vascular health, and its dysfunction is a major risk factor for cardiovascular diseases (CVD). Non-invasive neuromodulation techniques, such as NESA, aim to improve vascular tone and function by targeting the autonomic nervous system. However, evidence regarding their acute vascular eects is still limited. Methods: A randomized controlled trial was conducted with 40 participants divided into NESA (n = 20) and placebo (n = 20) groups. Both groups underwent 20-min interventions. Sonographic assessments of the left CCA, including lumen diameter (LD), intima-media thickness (IMT), and peak systolic velocity (PSV), along with blood pressure (BP) and heart rate (HR), were performed before and immediately after the intervention. Results: Significant increases in LD and cross-sectional area (CSA) were observed in the NESA group compared to placebo (p < 0.001), alongside a decrease in IMT (p < 0.05). HR showed a significant reduction post-intervention in both groups, with a more pronounced eect in the NESA group (p = 0.001). No significant changes were found in BP or PSV. Discussion: The findings demonstrate that NESA neuromodulation induces immediate changes in vascular parameters, including increased LD and CSA and decreased IMT. These results highlight measurable acute vascular eects in healthy individuals following NESA intervention.engArteria carótida comúnUltrasonido enfocado transrectal de alta intensidadjournal article10.3389/fnins.2025.1526236open accessSistema cardiovascularSistema nerviosoGoal 3: Ensure healthy lives and promote well-being for all at all agesGoal 9: Build resilient infrastructure, promote sustainable industrialization and foster innovation