Morales Rojas, Javier SalvadorValenzuela Ruiz, Pedro LuisRincón Castanedo, CeciliaSantos Lozano, AlejandroFiuza Luces, María del CarmenLucía Mulas, Alejandro2020-03-282020-03-282019Morales Rojas, J. S., Valenzuela Ruiz, P. L., Rincón-Castanedo, C., Santos-Lozano, A., Fiuza-Luces, C., & Lucía Mulas, A. (2019). Is health status impaired in childhood cancer survivors? A systematic review and meta-analysis. Critical Reviews in Oncology/Hematology, 142, 94–118. https://doi.org/10.1016/j.critrevonc.2019.07.0081040-84281879-0461http://hdl.handle.net/11268/8883Background An increase in survival rates of childhood cancer is associated with long-term health issues in survivors. Methods We conducted a systematic review and meta-analysis comparing health status-related endpoints in childhood cancer survivors (CCS) versus controls. Results Eighty-six studies (n = 98,480 participants, 62% CCS) were included in the review. Of these, 73 studies (n = 96,550, 63% CCS) could be meta-analyzed. CCS showed a lower left ventricular ejection and fractional shortening (SMD=-0.59 and -0.55, respectively, both p < 0.01 [n=1,824 and 1,880]), a lower HDL-cholesterol concentration (SMD=-0.48, p<0.001, n=1,378) and a higher waist-to-hip ratio (SMD=0.61, p < 0.01, n=229) than their healthy peers. No significant differences were found for the remaining endpoints. Conclusions CCS is associated with a lower left ventricular function and HDL-cholesterol level, and a higher waist-to-hip ratio than healthy controls. These findings support the need to closely monitor the cardiometabolic health status of CCS and to implement preventive lifestyle interventions for this population.engjournal article10.1016/j.critrevonc.2019.07.008restricted accessCáncerPediatríaEstilos de vidaCáncerPediatríaEstilo de vida