Martínez Sellés Oliveria Soares, ManuelDatino Romaniega, TomásAlhama, MartaBarrueco, NélidaCastillo Fernández, Isabel MaríaFernández-Avilés, Francisco2013-11-272013-11-272008Martínez-Sellés, M., Datino, T., Alhama, M., Barrueco, N., Castillo, I., & Fernández-Avilés, F. (2008). Rapid carvedilol up-titration in hospitalized patients with systolic heart failure. The Journal of Heart and Lung Transplantation, 27(8), 914-916.http://hdl.handle.net/11268/841To determine whether carvedilol can be safely up-titrated before hospital discharge, we studied 372 consecutive patients with systolic heart failure who were being treated with carvedilol. Carvedilol was initiated a median of 3 days after admission, with a mean starting dose of 12 mg. Up-titration was performed in 67% of patients, with a mean increase of 16 mg and a mean discharge daily dose of 23 +/- 17 mg. Mean daily dose at the end of follow-up was 35.3 +/- 25.3 mg and it increased with higher discharge dose.engjournal article10.1016/j.healun.2008.05.008restricted accessEnfermedad cardiovascularTratamiento médico