Núñez, JulioMiñana, GemaEspriella, Rafael de laZeigrí-Reiriz, IsabelComín Colet, J.Rubio Gracia, JorgeMorales Rull, José LuisLlácer, PauDíez Villanueva, PabloJuan Bagudá, Javier deEt. al.2025-10-132025-10-132025Núñez, J., Miñana, G., De La Espriella, R., Zegrí‐Reiriz, I., Comín‐Colet, J., Rubio Gracia, J., Morales‐Rull, J. L., Llàcer, P., Diez‐Villanueva, P., De Juan Bagudá, J., Ortiz Cortés, C., Goirigolzarri‐Artaza, J., García‐Pinilla, J. M., Barrios, E., Del Prado Díaz, S., Jiménez‐Marrero, S., Restrepo‐Córdoba, M. A., Testani, J., & Cobo Marcos, M. (2025). Salt repletion and diuretic response: The role of serum chloride. A post‐hoc analysis of the SALT ‐ HF trial on furosemide and hypertonic saline solution administration in ambulatory patients with worsening heart failure. European Journal of Heart Failure, 27(6), 960-971. https://doi.org/10.1002/ejhf.35971879-08441388-9842https://hdl.handle.net/11268/16385The efficacy of combining hypertonic saline solution (HSS) with loop diuretics in worsening heart failure (WHF) remains uncertain. Hypochloraemia has been associated with reduced diuretic efficacy. Some authors propose that chloride repletion may enhance natriuretic and diuretic responses. This post-hoc analysis of the SALT-HF trial evaluated the effect of single-dose administration of HSS plus intravenous (IV) furosemide versus IV furosemide, stratified by baseline serum chloride.engElectrólitosInfarto del MiocardioMonitoreo Fisiológicojournal article10.1002/ejhf.3597embargoed accessSistema cardiovascularProceso químicoGoal 3: Ensure healthy lives and promote well-being for all at all ages